Quantitative Biomedical Imaging
- Title
- DCE-MRI biomarkers in the clinical evaluation of antiangiogenic and vascular disrupting agents
- Authors
- J P B O'Connor, A Jackson, G J M Parker and G C Jayson
- Journal
- Brit. J. Cancer
- Link
- http://www.nature.com/bjc/journal/v96/n2/abs/6603515a.html
- Year
- 2007
- Volume
- 96
- Pages
- 189–95
- Month
- January
- Abstract
- Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) is now frequently used in early clinical trial assessment of antiangiogenic and vascular disrupting compounds. Evidence of drug efficacy and dose-dependent response has been demonstrated with some angiogenesis inhibitors. This review highlights the critical issues that influence T1-weighted DCE-MRI data acquisition and analysis, identifies important areas for future development and reviews the clinical trial findings to date.