Publications
Journal Papers
2011
J P B O'Connor, C J Rose, A Jackson, Y Watson, S Cheung, F Maders, B J Whitcher, C Roberts, G A Buonaccorsi, G Thompson, A R Clamp, G C Jayson and G J M Parker. DCE-MRI biomarkers of tumour heterogeneity predict CRC liver metastasis shrinkage following bevacizumab and FOLFOX-6. British Journal of Cancer 105(N/A): 139–145, 2011.
Caleb Roberts, Ross Little, Yvonne Watson, Sha Zhao, David L. Buckley, Geoff J. M. Parker. The Effect of Blood Inflow and B-1-Field Inhomogeneity on Measurement of the Arterial Input Function in Axial 3D Spoiled Gradient Echo Dynamic Contrast-Enhanced MRI. Mag Reson Med 65(1): 108–119, 2011.
2010
J.H. Naish, C.E. Hutchinson, A. Caunce, C. Roberts, J.C. Waterton, P.D. Hockings, C.J. Taylor, G.J.M. Parker. Multiple-Bolus Dynamic Contrast-Enhanced MRI in the Pancreas During a Glucose Challenge. J Mag Reson Imag 32(3): 622–628, 2010.
Lucy E. Kershaw, Josephine H. Naish, Deirdre M. McGrath, John C. Waterton, Geoffrey J. M. Parker. Measurement of Arterial Plasma Oxygenation in Dynamic Oxygen-Enhanced MRI. Mag Reson Med 64(6): 1838–1842, 2010.
Ying-Kiat Zee, James P. B. O'Connor, Geoff J. M. Parker, Alan Jackson, Andrew R. Clamp, M. Ben Taylor, Noel W. Clarke and Gordon C. Jayson. Imaging angiogenesis of genitourinary tumors. Nature Reviews Urology 7(-): 69–82, 2010.
S.J. Mills, C. Soh, J.P.B. O'Connor, C.J. Rose, G. Buonaccorsi, S. Cheung, S. Zhao, G.J.M. Parker and A. Jackson. Enhancing Fraction in Glioma and Its Relationship to the Tumoral Vascular Microenvironment: A Dynamic Contrast-Enhanced MR Imaging Study. Am J Neuroradiol 31(4): 726–731, 2010.
C. L. Mitchell, J. P. B. O'Connor, A. Jackson, G. J. M. Parker, C. Roberts, Y. Watson, S. Cheung, K. Davies, G. A. Buonaccorsi, A. R. Clamp, J. Hasan, L. Byrd, A. Backen, C. Dive and G. C. Jayson. Identification of early predictive imaging biomarkers and their relationship to serological angiogenic markers in patients with ovarian cancer with residual disease following cytotoxic therapy. Ann Oncol 21(10): 1982–1989, 2010.
Lauren J. Bains, Deirdre M. McGrath, Josephine H. Naish, Susan Cheung, Yvonne Watson, M. Ben Taylor, John P. Logue, Geoffrey J. M. Parker, John C. Waterton, David L. Buckley. Tracer Kinetic Analysis of Dynamic Contrast-Enhanced MRI and CT Bladder Cancer Data: A Preliminary Comparison to Assess the Magnitude of Water Exchange Effects. Mag Reson Med 64(2): 595–603, 2010.
G. A. Buonaccorsi, C. J. Rose, J. P. B. O’Connor, C. Roberts, Y. Watson, A. Jackson, G. C. Jayson and G. J. M. Parker. Cross-Visit Tumor Sub-segmentation and Registration with Outlier Rejection for Dynamic Contrast-Enhanced MRI Time Series Data. Lecture Notes in Computer Science 6363/2010(-): 121–128, 2010.
2009
Chris J. Rose, Samantha J. Mills, James P. B. O'Connor, Giovanni A. Buonaccorsi, Caleb Roberts, Yvonne Watson, Susan Cheung, Sha Zhao, Brandon Whitcher, Alan Jackson, Geoffrey J. M. Parker. Quantifying Spatial Heterogeneity in Dynamic Contrast-Enhanced MRI Parameter Maps. Magnetic Resonance in Medicine 62(2): 488-499, 2009.
James P.B. O'Connor, Richard A.D. Carano, Andrew R. Clamp, Jed Ross, Calvin C.K. Ho, Alan Jackson, Geoff J.M. Parker, Chris J. Rose, Franklin V. Peale, Michel Friesenhahn, Claire L. Mitchell, Yvonne Watson, Caleb Roberts, Lynn Hope, Sue Cheung, Hani Bou Reslan, Mary Ann T. Go, Glenn J. Pacheco, Xiumin Wu, Tim C. Cao, Sarajane Ross, Giovanni A. Buonaccorsi, Karen Davies, Jurjees Hasan, Paula Thornton, Olivia del Puerto, Napoleone Ferrara, Nicholas van Bruggen and Gordon C. Jayson. Quantifying Antivascular Effects of Monoclonal Antibodies to Vascular Endothelial Growth Factor: Insights from Imaging. Clin Cancer Res 15(21): 6674–6682, 2009.
J.P.B. O'Connor, J.H. Naish, G.J.M. Parker, J.C. Waterton, Y. Watson, G.C. Jayson, G.A. Buonaccorsi, S. Cheung, D.L. Buckley, D.M. McGrath, C.M.L. West, S.E. Davidson, C. Roberts, S.J. Mills, C.L. Mitchell, L. Hope, N.C. Ton and A. Jackson. Preliminary Study of Oxygen-Enhanced Longitudinal Relaxation in MRI: A Potential Novel Biomarker of Oxygenation Changes in Solid Tumors. Int. J. Radiation Oncology Biol. Phys. 75(4): 1209-1215, 2009.
Josephine H. Naish, Lucy E. Kershaw, David L. Buckley, Alan Jackson, John C. Waterton, Geoffrey J.M. Parker. Modeling of contrast agent kinetics in the lung using T1-weighted dynamic contrast-enhanced MRI. Magnetic Resonance in Medicine 61(6): 1507–14, 2009.
Samantha J. Mills, Calvin Soh, James P. B. O’Connor, Chris J. Rose, Giovanni A. Buonaccorsi, Susan Cheung, Sha Zhao, Geoff J. M. Parker and Alan Jackson. Tumour enhancing fraction (EnF) in glioma: relationship to tumour grade. European Radiology 9(8): 766–76, 2009.
Deirdre M. McGrath, Daniel P. Bradley, Jean L. Tessier, Tony Lacey, Chris J. Taylor, Geoffrey J.M. Parker. Comparison of Model-Based Arterial Input Functions for Dynamic Contrast-Enhanced MRI in Tumor Bearing Rats. Mag Reson Med 61(5): 1173–1184, 2009.
S.J. Mills, C. Soh, C.J. Rose, S. Cheung, S. Zhao, G.J.M. Parker and A. Jackson. Candidate Biomarkers of Extravascular Extracellular Space: A Direct Comparison of Apparent Diffusion Coefficient and Dynamic Contrast-Enhanced MR Imaging-Derived Measurement of the Volume of the Extravascular Extracellular Space in Glioblastoma Multiforme. Am J Neuroradiol 31(3): 549–553, 2009.
2008
Caleb Roberts, Geoff J. M. Parker, Chris J. Rose, Yvonne Watson, James P. O'Connor, Stavros M. Stivaros, Alan Jackson, and Vivian E. Rushton. Glandular Function in Sjögren Syndrome: Assessment with Dynamic Contrast-enhanced MR Imaging and Tracer Kinetic Modeling—Initial Experience. Magn. Reson. Med. 246(3): 845–53, 2008.
McGrath DM, Naish JH, O'Connor JP, Hutchinson CE, Waterton JC, Taylor CJ, Parker GJ. Oxygen-induced changes in longitudinal relaxation times in skeletal muscle. Magn. Reson. Med. 26(2): 221–7, 2008.
Deirdre M. McGrath, Josephine H. Naish, James P.B. O'Connor, Charles E. Hutchinson, John C. Waterton, Chris J. Taylor and Geoffrey J.M. Parker. Oxygen-induced changes in longitudinal relaxation times in skeletal muscle. Magnetic Resonance Imaging 26(2): 221–7, 2008.
James PB O'Connor, Alan Jackson, Marie-Claude Asselin, David L Buckley, Geoff JM Parker, Gordon C Jayson. Quantitative Imaging Biomarkers in the Clinical Development of Targeted Therapeutics: Current and Future Perspectives. The Lancet Oncology 9(7): 1489-1498, 2008.
James P.B. O'Connor 1 2, Josephine H. Naish, Alan Jackson, John C. Waterton, Yvonne Watson, Sue Cheung, David L. Buckley, Deirdre M. McGrath, Giovanni A. Buonaccorsi, Samantha J. Mills, Caleb Roberts, Gordon C. Jayson, Geoff J.M. Parker. Comparison of normal tissue R1 and R2* modulation by oxygen and carbogen. Magnetic Resonance in Medicine 61(1): 75–83, 2008.
2007
John P. Carr, David L. Buckley, Jean Tessier, Geoff J.M. Parker. What levels of precision are achievable for quantification of perfusion and capillary permeability surface area product using ASL?. Mag. Reson. Med. 58(2): 281–9, 2007.
J.P.B. O’Connor, A. Jackson, G.A. Buonaccorsi, Y. Watson, S. Cheung, C. Roberts, D.M. McGrath, J.H Naish, C. Rose, P.M. Dark, G.C. Jayson, D.L. Buckley, G.J.M. Parker. Organ-specific effects of oxygen and carbogen gas inhalation on tissue longitudinal relaxation times. Magn. Reson. Med. 58(3): 490–496, 2007.
G.A. Buonaccorsi, J.P.B. O’Connor, A. Caunce, C. Roberts, S. Cheung, Y. Watson, K. Davies, A. Jackson, G.C. Jayson, G.J.M. Parker. Tracer kinetic model driven registration for DCE-MRI time-series data. Clin. Cancer Res. 58(5): 1010–9, 2007.
James P.B. O'Connor, Gordon C. Jayson, Alan Jackson, Dana Ghiorghiu, Bernadette M. Carrington, Chris J. Rose, Samantha J. Mills, Ric Swindell, Caleb Roberts, Claire L. Mitchell and Geoffrey J.M. Parker. Enhancing Fraction Predicts Clinical Outcome following First-Line Chemotherapy in Patients with Epithelial Ovarian Carcinoma. Clin. Cancer Res. 13(N/A): 6130–5, 2007.
Alan Jackson, James P.B. O'Connor, Geoff J.M. Parker and Gordon C. Jayson. Imaging Tumor Vascular Heterogeneity and Angiogenesis using Dynamic Contrast-Enhanced Magnetic Resonance Imaging. Clin. Cancer Res. 13(N/A): 3449–59, 2007.
J P B O'Connor, A Jackson, G J M Parker and G C Jayson. DCE-MRI biomarkers in the clinical evaluation of antiangiogenic and vascular disrupting agents. Brit. J. Cancer 96(N/A): 189–95, 2007.
Saifee A. Mullamitha, Nhuan C. Ton, Geoff J.M. Parker, Alan Jackson, Peter J. Julyan, Caleb Roberts, Gio A. Buonaccorsi, Yvonne Watson, Karen Davies, Sue Cheung, Lynn Hope, Juan W. Valle, John A. Radford, Jeremy Lawrance, Mark P. Saunders, Mihaela C. Munteanu, Marian T. Nakada, Jeffrey A. Nemeth, Hugh M. Davis, Qun Jiao, Uma Prabhakar, Zhihui Lang, Robert E. Corringham, Robert A. Beckman, Gordon C. Jayson in association with the Biotherapy Development Association. Phase I Evaluation of a Fully Human Anti–αv Integrin Monoclonal Antibody (CNTO 95) in Patients with Advanced Solid Tumors. Clin. Cancer Res. 13(N/A): 2128–35, 2007.
N.C. Ton, G.J. Parker, A. Jackson, S. Mullamitha, G.A. Buonaccorsi, C. Roberts, Y. Watson, K. Davies, S. Cheung, L. Hope, F. Power, J. Lawrance, J. Valle, M. Saunders, R. Felix, J.A. Soranson, L. Rolfe, K. Zinkewich-Peotti, G.C. Jayson. Phase I Evaluation of CDP791, a PEGylated Di-Fab' Conjugate that Binds Vascular Endothelial Growth Factor Receptor 2. Clin. Cancer Res. 13(N/A): 7113–8, 2007.
2006
Geoff J.M. Parker, Caleb Roberts, Andrew Macdonald, Giovanni A. Buonaccorsi, Sue Cheung, David L. Buckley, Alan Jackson, Yvonne Watson, Karen Davies, Gordon C. Jayson. Experimentally-derived functional form for a population-averaged high-temporal-resolution arterial input function for dynamic contrast-enhanced MRI. Mag. Reson. Med. 56(5): 993–1000, 2006.
Caleb Roberts, David L. Buckley, Geoff J.M. Parker. Comparison of errors associated with single- and multi-bolus injection protocols in low-temporal-resolution dynamic contrast-enhanced tracer kinetic analysis. Mag. Reson. Med. 56(3): 611–9, 2006.
Giovanni A. Buonaccorsi, Caleb Roberts, Sue Cheung, Yvonne Watson, James P.B. O’Connor, Karen Davies, Alan Jackson, Gordon C. Jayson, Geoff J.M. Parker. Comparison of the Performance of Tracer Kinetic Model-Driven Registration for Dynamic Contrast Enhanced MRI Using Different Models of Contrast Enhancement. Acad. Radiology 13(9): 1112–1123, 2006.
Caleb Roberts, Basma Issa, Andrew Stone, Alan Jackson, John C. Waterton, Geoffrey J.M. Parker. Comparative study into the robustness of compartmental modeling and model-free analysis in DCE-MRI studies. J. Mag. Reson. Imag. 23(4): 554–63, 2006.
S.J. Mills, T.A. Patankar, H.A. Haroon, D. Balériaux, R. Swindell and A. Jackson. Do Cerebral Blood Volume and Contrast Transfer Coefficient Predict Prognosis in Human Glioma?. Am. J. Neuroradiology 27(N/A): 853–8, 2006.
2005
Tufail F. Patankar, Hamied A. Haroon, Samantha J. Mills, Danielle Balériaux, David L. Buckley, Geoff J.M. Parker and Alan Jackson. Is Volume Transfer Coefficient (Ktrans) Related to Histologic Grade in Human Gliomas?. Am. J. Neuroradiology 26(N/A): 2455–65, 2005.
Josephine H. Naish, Geoffrey J. M. Parker, Paul C. Beatty, Alan Jackson, Simon S. Young, John C. Waterton, Chris J. Taylor. Improved quantitative dynamic regional oxygen-enhanced pulmonary imaging using image registration. Mag. Reson. Med. 54(2): 464–9, 2005.
G.C. Jayson, G.J.M. Parker, S. Mullamitha, J.W. Valle, M. Saunders, L. Broughton, J. Lawrance, B. Carrington, C. Roberts, B. Issa, D.L. Buckley, S. Cheung, K. Davies, Y. Watson, K. Zinkewich-Péotti, L. Rolfe, A. Jackson. Blockade of Platelet-Derived Growth Factor Receptor-Beta by CDP860, a Humanized, PEGylated di-Fab', Leads to Fluid Accumulation and Is Associated With Increased Tumor Vascularized Volume. J. Clin. Oncology 23(5): 973–81, 2005.
2004
Harrer JU, Parker GJ, Haroon HA, Buckley DL, Embelton K, Roberts C, Balériaux D, Jackson A. Comparative study of methods for determining vascular permeability and blood volume in human gliomas. J. Mag. Reson. Imag. 20(5): 748–57, 2004.
David L. Buckley, Caleb Roberts, Geoff J. M. Parker, John P. Logue and Charles E. Hutchinson. Prostate Cancer: Evaluation of Vascular Characteristics with Dynamic Contrast-enhanced T1-weighted MR Imaging—Initial Experience. Radiology 223(3): 709–15, 2004.
2002
Neil G. Harris, Victoria Gauden, Paul A. Fraser, Stephen R. Williams, Geoff J. M. Parker. MRI measurement of blood-brain barrier permeability following spontaneous reperfusion in the starch microsphere model of ischemia. J. Mag. Reson. Imag. 20(3): 221–30, 2002.
2001
Geoffrey J.M. Parker, Gareth J. Barker, Paul S. Tofts. Accurate multislice gradient echo T1 measurement in the presence of non-ideal RF pulse shape and RF field nonuniformity. Mag. Res. Med. 45(5): 838–45, 2001.
Anwar R. Padhani, A. David MacVicar, Connie J. Gapinski, David P. Dearnaley, Geoffrey J. M. Parker, John Suckling, Martin O. Leach and Janet E. Husband. Effects of Androgen Deprivation on Prostatic Morphology and Vascular Permeability Evaluated with MR Imaging. Radiology 218(N/A): 365–74, 2001.
2000
Geoffrey J.M Parker, Isabelle Baustert, Steven F Tanner, Martin O Leach. Improving image quality and T1 measurements using saturation recovery turboFLASH with an approximate K-space normalisation filter. J. Mag. Reson. Imag. 18(2): 157–67, 2000.
Anwar R. Padhani, Connie J. Gapinski, David A. MacVicar, Geoffrey J. Parker, John Suckling, Patrick B. Revell, Martin O. Leach, David P. Dearnaley, Janet E. Husband. Dynamic Contrast Enhanced MRI of Prostate Cancer: Correlation with Morphology and Tumour Stage, Histological Grade and PSA. Clinical Radiology 55(2): 99-109, 2000.
1999
P.S. Tofts, G. Brix, D.L. Buckley, J.L. Evelhoch, E. Henderson, M. Knopp, H.B.W. Larsson, T. Y. Lee, N.A. Mayr, G.J.M. Parker, R.E. Port, J. Taylor, R.M. Weisskoff. Estimating kinetic parameters from dynamic contrast-enhanced t1-weighted MRI of a diffusable tracer: Standardized quantities and symbols. J. Mag. Res. Imag. 10(3): 223–32, 1999.
1998
GJ Parker, J Suckling, SF Tanner, AR Padhani, JE Husband and MO Leach. MRIW: parametric analysis software for contrast-enhanced dynamic MR imaging in cancer. RadioGraphics 18(N/A): 497–506, 1998.
1997
Geoffrey J. M. Parker, John Suckling, Steven F. Tanner, Anwar R. Padhani, Patrick B. Revell, Janet E. Husband, Martin O. Leach. Probing tumor microvascularity by measurement, analysis and display of contrast agent uptake kinetics. J. Mag. Res. Imag. 7(3): 564–74, 1997.