Software, Image Data, Materials and Phantoms

 

Tissue Mimetic Materials & Phantoms for Diffusion MRI

We have developed tissue mimetic phantoms for use with diffusion MRI. The novel materials involved mimic the important features of cellular microstructure with a high degree to geometrical accuracy and therefore allow testing of models of tissue microstructure and for calibration of ADC and diffusion anisotropy measurements. These phantoms have been designed to mimic a range of tissues, including the white matter and grey matter of the brain, tumours, and the myocardium. References include:

White matter mimics

F. Zhou, Z. Li, J. Gough, P.L. Hubbard Cristinacce, G.J.M. Parker. Axon mimicking hydrophilic hollow polycaprolactone microfibres for diffusion magnetic resonance imaging. Materials & Design, 137, 394–403, (2018). doi: 10.1016/j.matdes.2017.10.047

M. Grech-Sollars, F.-L. Zhou, A.D. Waldman, G.J.M. Parker, P.L. Hubbard Cristinacce. Stability and reproducibility of co-electrospun brain-mimicking phantoms for quality assurance of diffusion MRI sequences. NeuroImage, 181, 395-402, (2018) doi: 10.1016/j.neuroimage.2018.06.059

P.L. Hubbard, F.-L. Zhou, S.J. Eichhorn, G.J.M. Parker. Biomimetic Phantom for the Validation of Diffusion Magnetic Resonance Imaging. Magn. Reson. Med. 73(1), 299-305, (2015). doi: 10.1002/mrm.25107

FL Zhou, PL Hubbard, SJ Eichhorn, GJ Parker. Coaxially electrospun axon-mimicking fibers for diffusion magnetic resonance imaging. ACS Applied Materials and Interfaces 4(11): 6311–16, 2012. doi: 10.1021/am301919s

F-L Zhou, PL Hubbard, SJ Eichhorn, GJM Parker. Jet deposition in near-field electrospinning of patterned single component and core-shell fibres. Polymer 52(16), 3603-3610,(2011).

Grey matter mimics

M. Grech-Sollars, F.-L. Zhou, A.D. Waldman, G.J.M. Parker, P.L. Hubbard Cristinacce. Stability and reproducibility of co-electrospun brain-mimicking phantoms for quality assurance of diffusion MRI sequences. NeuroImage, 181, 395-402, (2018) doi: 10.1016/j.neuroimage.2018.06.059

Tumour tissue mimics

D.J. McHugh, F.‐L. Zhou, I. Wimpenny, G. Poologasundarampillai, J.H. Naish, P.L. Hubbard Cristinacce, G.J.M. Parker. A biomimetic tumor tissue phantom for validating diffusion‐weighted MRI measurements. Magn. Reson. Med. 80(1), 147-158, (2018). doi: 10.1002/mrm.27016

  • Example data and MATLAB code for microstructural modelling of biomimetic tumour tissue phantoms can be found here.

F. Zhou, A. Chirazi, J. Gough, P. Hubbard Cristinacce, G.J.M. Parker. Hollow polycaprolactone microspheres with/without single surface hole by co-electrospraying. 33(46), 13262-13271, Langmuir (2017). doi: 10.1021/acs.langmuir.7b01985

F.-L. Zhou, P.L. Hubbard Cristinacce, S.J. Eichhorn, G.J.M. Parker. Preparation and characterization of polycaprolactone microspheres by electrospraying. Aerosol Science and Technology, 50(11), 1201-1215, (2016) doi: 10.1080/02786826.2016.1234707

Myocardium mimics

I. Teh, F.-L. Zhou, P.L. Hubbard Cristinacce, G.J.M. Parker, J.E. Schneider. Biomimetic phantom for cardiac diffusion MRI. J Magn. Reson. Imag. 43(3), 594-600, (2016). doi: 10.1002/jmri.25014, Front cover

Obtaining Phantoms & Materials

We are open to collaborations regarding the use of our materials for diffusion MRI purposes or other tissue mimicking applications. Contact us for further information.

Software

DCE-MRI digital phantom

We are also able to make software for DCE-MRI digital phantom generation available. Please contact us to find out more.

Microstructural modelling of biomimetic tumour tissue phantoms

Example data and MATLAB code for microstructural modelling of biomimetic tumour tissue phantoms (McHugh, et al. Magn. Reson. Med. 80, 147-158, (2018); see above) can be found here. Contact us for further information.

Funding

This work has been funded:

  • as part of the CONNECT consortium within the Future and Emerging Technologies (FET) Programme within the Seventh Framework Programme for Research of the European Commission, under FET-Open Grant 238292.
  • as part of the Cancer Research UK/EPSRC Cancer Imaging Centre in Cambridge and Manchester, grant number C8742/A18097.
  • as part of the EPSRC grant OCEAN: One-stop-shop microstructure-sensitive perfusion/diffusion MRI: Application to vascular cognitive impairment, grant number EP/M006328/1.
  • as part of the Wellcome Trust ISSF award 097820/Z/11/B.

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