Software, Image Data and Phantoms
Tissue Mimetic Phantoms for Diffusion MRI
We have developed tissue mimetic phantoms for use with diffusion MRI. The novel materials involved mimic the important features of cellular microstructure with a high degree to geometrical accuracy and therefore allow testing of models of tissue microstructure and for calibration of ADC and diffusion anisotropy measurements. These phantoms have been designed to mimic a range of tissues, including the white matter and grey matter of the brain, tumours, and the myocardium.
F. Zhou, Z. Li, J. Gough, P.L. Hubbard Cristinacce, G.J.M. Parker. "Axon mimicking hydrophilic hollow polycaprolactone microfibres for diffusion magnetic resonance imaging." Materials & Design, 137, 394–403, (2018). doi: 10.1016/j.matdes.2017.10.047
I. Teh, F.-L. Zhou, P.L. Hubbard Cristinacce, G.J.M. Parker, J.E. Schneider. "Biomimetic phantom for cardiac diffusion MRI." J Magn. Reson. Imag. 43(3), 594-600, (2016). doi: 10.1002/jmri.25014, Front cover
F.-L. Zhou, P.L. Hubbard Cristinacce, S.J. Eichhorn, G.J.M. Parker. "Preparation and characterization of polycaprolactone microspheres by electrospraying." Aerosol Science and Technology, 50(11), 1201-1215, (2016) doi: 10.1080/02786826.2016.1234707
P.L. Hubbard, F.-L. Zhou, S.J. Eichhorn, G.J.M. Parker. "Biomimetic Phantom for the Validation of Diffusion Magnetic Resonance Imaging." Magn. Reson. Med. 73(1), 299-305, (2015). doi: 10.1002/mrm.25107.
FL Zhou, PL Hubbard, SJ Eichhorn, GJ Parker. "Coaxially electrospun axon-mimicking fibers for diffusion magnetic resonance imaging." ACS Applied Materials and Interfaces 4(11): 6311–16, 2012. doi: 10.1021/am301919s
F-L Zhou, PL Hubbard, SJ Eichhorn, GJM Parker. Jet deposition in near-field electrospinning of patterned single component and core-shell fibres. Polymer 52(16), 3603-3610,(2011).
Obtaining Phantom Materials
We are open to collaborations regarding the use of our materials fro diffusion MRI purposes or other tissue mimicking applications.
This work has been funded:
- as part of the CONNECT consortium within the Future and Emerging Technologies (FET) Programme within the Seventh Framework Programme for Research of the European Commission, under FET-Open Grant 238292
- as part of the Cancer Research UK/EPSRC Cancer Imaging Centre in Cambridge and Manchester grant number C8742/A18097.
Please contact us to find out more.
We are also able to make software for DCE-MRI digital phantom generation available. Please contact us to find out more.
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